Endocrine Abstracts

Background: The treatment of choice in prolactinomas are dopamine agonists, with surgery reserved for cases refractory to or poorly tolerant of pharmacotherapy. Little is known on the associations between clinical, neuroradiological and pathological features influencing the efficacy of transphenoidal surgery.The Aim: To evaluate clinical, neuroradiological and neuropathological aspects of surgically treated prolactinomas in women, with a particular empha...

Background: O-6-Methylguanine-DNA-methyltransferase (MGMT) is a DNA repair enzyme. It has been demonstrated that its higher expression counteracts cytotoxicity of alkylating agents used in the treatment of glioblastoma or invasive pituitary tumors. Little is known on the relationships between MGMT expression and invasiveness of corticotroph adenomas in Cushing disease (CD).The Aim: To evaluate MGMT expression and its associations with clinical, neuropath...